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[JN4985]兔抗MLKL多克隆抗体

价格:0

货号:JN4985

规格: 100ul 200ul 25ul

联系方式:021-54479081

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中文名称 :   兔抗MLKL多克隆抗体

英文名称 :  Anti-MLKL rabbit polyclonal antibody


别       名 :  mixed lineage kinase domain like pseudokinase; hMLKL


相关类别 :  一抗


储       存 :  冷冻(-20℃)


宿       主 :  Rabbit


抗       原 :  MLKL


反应种属 :  Human


标 记 物 :  Unconjugate


克隆类型 :  rabbit polyclonal


技术规格


Background:

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

Applications:

ELISA, IHC

Name of antibody:

MLKL

Immunogen:

Fusion protein of human MLKL

Full name:

mixed lineage kinase domain like pseudokinase

Synonyms:

hMLKL

SwissProt:

Q8NB16

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and Human tonsil

IHC Recommend dilution:

50-300







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